Inspired by the hit video game, players collect treasure, defeat monsters, and be the first to collect four souls. Discover killer combos, enhance your abilities, betray your companions and win!

UPDATED: This is the Second Edition of The Binding of Isaac: Four Souls. All cards have been updated with enhanced backgrounds and updated wording for clarity.

BACK TO THE BASEMENT: Return to Mom’s basement in this 2nd Edition of The Binding of Isaac: Four Souls! Expand your experience with a brand new Solitaire and Co-Op Mode. With nearly 350 cards, replay is almost endless.

FRIEND OR FOE: Players can cooperate to fight powerful bosses or sabotage each other.

One to four players take turns playing loot cards and using items to kill monsters that yield more items, loot, and sometimes souls. The first player to end their turn with four souls is the winner!