This is the Second Edition of The Binding of Isaac: Four Souls+. This was the first expansion to The Binding of Isaac: Four Souls and is contained in a tuckbox. This is the second edition that includes enhanced backgrounds and updated wording for clarity.
The Expansion Includes:
98 The Binding of Isaac: Four Souls+ 2nd Edition cards
![Dragonfire Blade Art Card (40/54) [Tarkir: Dragonstorm Art Series]](https://www.playmtgsingle.com/wp-content/uploads/2026/06/1780987992/dragonfire-blade-art-card-40-54-tarkir-dragonstorm-art-series.webp)
![Wooden Cane Art Card (Gold-Stamped) [Teenage Mutant Ninja Turtles Art Series]](https://www.playmtgsingle.com/wp-content/uploads/2026/06/1780987998/wooden-cane-art-card-gold-stamped-teenage-mutant-ninja-turtles-art-series.webp)
![Caradora, Heart of Alacria Art Card (14/54) [Aetherdrift Art Series]](https://www.playmtgsingle.com/wp-content/uploads/2026/06/1780987998/caradora-heart-of-alacria-art-card-14-54-aetherdrift-art-series.webp)